Reactome | Endosome acidification

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Endosome acidification Show undefined attributes

authored	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
catalystActivity	[CatalystActivity:912612] proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]
category	transition
compartment	[Compartment:17940] endosome
created	[InstanceEdit:74963] Bevan, AP, 2003-07-31 08:01:55
crossReference	[DatabaseIdentifier:12667475] RHEA:34979
dbId	74723
displayName	Endosome acidification
edited	[InstanceEdit:927729] Jassal, B, 2010-08-09
eventOf	[Pathway:R-HSA-77387] Insulin receptor recycling - Homo sapiens
figure	[Figure:74813] /figures/ins_endosacid.jpg
followingEvent	[Reaction:R-HSA-74726] Dissociation of insulin from insulin receptor - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:76093] Insulin degradation: mechanisms, products, and significance. [LiteratureReference:76095] Insulin degradation: progress and potential. [LiteratureReference:76096] Endosomal proteolysis of internalized proteins.
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Endosome acidification
orthologousEvent	[Reaction:R-PFA-74723] Endosome acidification - Plasmodium falciparum [Reaction:R-SCE-74723] Endosome acidification - Saccharomyces cerevisiae [Reaction:R-SPO-74723] Endosome acidification - Schizosaccharomyces pombe [Reaction:R-DDI-74723] Endosome acidification - Dictyostelium discoideum [Reaction:R-CEL-74723] Endosome acidification - Caenorhabditis elegans [Reaction:R-DME-74723] Endosome acidification - Drosophila melanogaster [Reaction:R-GGA-74723] Endosome acidification - Gallus gallus [Reaction:R-XTR-74723] Endosome acidification - Xenopus tropicalis [Reaction:R-DRE-74723] Endosome acidification - Danio rerio [Reaction:R-SSC-74723] Endosome acidification - Sus scrofa [Reaction:R-BTA-74723] Endosome acidification - Bos taurus [Reaction:R-CFA-74723] Endosome acidification - Canis familiaris [Reaction:R-RNO-74723] Endosome acidification - Rattus norvegicus [Reaction:R-MMU-74723] Endosome acidification - Mus musculus
output	[SimpleEntity:R-ALL-74722] H+ [endosome lumen]
precedingEvent	[Reaction:R-HSA-5252133] ATP6AP1 binds V-ATPase - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:927730] He, Lei, 2010-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74723
summation	[Summation:74753] The effect of the proton pump is to allow entry of [H+] ions...
updateTrackers	[UpdateTracker:9790242] Update Tracker - [Reaction:74723] Endosome acidification - v34:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9790242] Update Tracker - [Reaction:74723] Endosome acidification - v34:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-77387] Insulin receptor recycling
(precedingEvent)	[Reaction:R-HSA-74726] Dissociation of insulin from insulin receptor