Reactome | Endosome acidification

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10833779] proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]
category	transition
compartment	[Compartment:17940] endosome
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10833781
displayName	Endosome acidification
eventOf	[Pathway:R-DME-77387] Insulin receptor recycling - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-74723] Endosome acidification - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Endosome acidification
output	[SimpleEntity:R-ALL-74722] H+ [endosome lumen]
precedingEvent	[Reaction:R-DME-5252133] ATP6AP1 binds V-ATPase - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-74723
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DME-77387] Insulin receptor recycling
(inferredTo)	[Reaction:R-HSA-74723] Endosome acidification

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