Reactome | Endosome acidification

Endosome acidification

Stable Identifier

R-HSA-74723

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome

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The effect of the proton pump is to allow entry of [H+] ions into the lumen of the endosome. The net effect of this is to lower the pH of the lumen from pH 7.4 (the pH at the plasma membrane) to pH 6.0 (documented with studies using FITC-labeled insulin - a pH dependent fluorescence marker).

Literature References

PubMed ID	Title	Journal	Year
3061785	Insulin degradation: mechanisms, products, and significance. Duckworth, WC	Endocr Rev	1989
9793760	Insulin degradation: progress and potential. Duckworth, WC, Bennett, RG, Hamel, FG	Endocr Rev	1998
8682206	Endosomal proteolysis of internalized proteins. Authier, F, Posner, BI, Bergeron, JJ	FEBS Lett	1996