Endosome acidification

Stable Identifier
R-HSA-74723
Type
Reaction
Species
Homo sapiens
Compartment
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The effect of the proton pump is to allow entry of [H+] ions into the lumen of the endosome. The net effect of this is to lower the pH of the lumen from pH 7.4 (the pH at the plasma membrane) to pH 6.0 (documented with studies using FITC-labeled insulin - a pH dependent fluorescence marker).

Literature References
PubMed ID Title Journal Year
9793760 Insulin degradation: progress and potential.

Duckworth, WC, Bennett, RG, Hamel, FG

Endocr Rev 1998
3061785 Insulin degradation: mechanisms, products, and significance.

Duckworth, WC

Endocr Rev 1989
8682206 Endosomal proteolysis of internalized proteins.

Bergeron, JJ, Authier, F, Posner, BI

FEBS Lett 1996
Participants
Input
Participates
Catalyst Activity

proton transmembrane transporter activity of V-ATPase:ATP6AP1 [endosome membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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