Reactome | uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]

Schema > Reaction > Entries

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] Show undefined attributes

catalystActivity	[CatalystActivity:73557] uridine phosphorylase activity of UPP1, UPP2 [cytosol]
catalystActivityReference	[CatalystActivityReference:9643140] uridine phosphorylase activity of UPP1, UPP2 [cytosol] Cloning and expression of human uridine phosphorylase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74362] D'Eustachio, P, 2003-07-18 15:39:00
crossReference	[DatabaseIdentifier:9976256] RHEA:24390 [DatabaseIdentifier:9976257] RHEA:22826
dbId	74372
deleted	[Deleted:500434] Deletion of instance: 74371
displayName	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
eventOf	[Pathway:R-HSA-73614] Pyrimidine salvage - Homo sapiens
input	[DefinedSet:R-ALL-500244] R1P, dRibP [cytosol] [SimpleEntity:R-ALL-83962] Ura [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:112252] Cloning and expression of human uridine phosphorylase [LiteratureReference:500431] Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy [LiteratureReference:977407] Identification of a novel human uridine phosphorylase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] alpha-D-ribose 1-phosphate + uracil => uridine + phosphate 2-deoxy-alpha-D-ribose 1-phosphate + uracil => 2'-deoxyuridine + phosphate
orthologousEvent	[Reaction:R-PFA-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Plasmodium falciparum [Reaction:R-DDI-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Dictyostelium discoideum [Reaction:R-CEL-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Caenorhabditis elegans [Reaction:R-DME-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Drosophila melanogaster [Reaction:R-GGA-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Gallus gallus [Reaction:R-XTR-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Xenopus tropicalis [Reaction:R-DRE-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Danio rerio [Reaction:R-SSC-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Sus scrofa [Reaction:R-BTA-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Bos taurus [Reaction:R-CFA-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Canis familiaris [Reaction:R-RNO-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Rattus norvegicus [Reaction:R-MMU-74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - Mus musculus
output	[DefinedSet:R-ALL-500430] (d)Ura [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
releaseDate	2004-07-06
reverseReaction	[Reaction:R-HSA-74376] (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74372
summation	[Summation:179290] Cytosolic uridine phosphorylase (isoforms UPP1 and UPP2) cat...
updateTrackers	[UpdateTracker:9791044] Update Tracker - [Reaction:74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9790037] Update Tracker - [Reaction:74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - v35:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791044] Update Tracker - [Reaction:74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - v32:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText] [UpdateTracker:9790037] Update Tracker - [Reaction:74372] uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP] - v35:[addLiteratureReference, modifyText]
(replacementInstances)	[Deleted:500434] Deletion of instance: 74371
(hasEvent)	[Pathway:R-HSA-73614] Pyrimidine salvage