Reactome | Guanine + H2O => Xanthine + NH4+

Guanine + H2O => Xanthine + NH4+

Stable Identifier

R-HSA-74255

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

guanine + H2O + H(+) => xanthine + NH4(+)

ReviewStatus

5/5

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Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19470646	Alteration of enzyme specificity by computational loop remodeling and design Murphy, PM, Bolduc, JM, Gallaher, JL, Stoddard, BL, Baker, D	Proc Natl Acad Sci U S A	2009
10075721	Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein. Yuan, G, Bin, JC, McKay, DJ, Snyder, FF	J Biol Chem	1999