Guanine + H2O => Xanthine + NH4+

Stable Identifier
R-HSA-74255
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Guanine + H2O => Xanthine + NH4+
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Cytosolic guanine deaminase (GDA) catalyzes the reaction of guanine and water to form xanthine and ammonia (Yuan et al. 1999). The active enzyme is a homodimer (Murphy et al. 2009).
Literature References
PubMed ID Title Journal Year
19470646 Alteration of enzyme specificity by computational loop remodeling and design

Murphy, PM, Bolduc, JM, Stoddard, BL, Baker, D, Gallaher, JL

Proc Natl Acad Sci U S A 2009
10075721 Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.

Snyder, FF, McKay, DJ, Bin, JC, Yuan, G

J Biol Chem 1999
Participants
Input
Output
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as an event of
Catalyst Activity

guanine deaminase activity of GDA dimer [cytosol]

Physical Entity
GDA dimer [cytosol] (Homo sapiens)
Activity
guanine deaminase activity (GO:0008892)
Orthologous Events
Guanine + H2O => Xanthine + NH4+ (Bos taurus)
Guanine + H2O => Xanthine + NH4+ (Canis familiaris)
Guanine + H2O => Xanthine + NH4+ (Danio rerio)
Guanine + H2O => Xanthine + NH4+ (Dictyostelium discoideum)
Guanine + H2O => Xanthine + NH4+ (Drosophila melanogaster)
Guanine + H2O => Xanthine + NH4+ (Gallus gallus)
Guanine + H2O => Xanthine + NH4+ (Mus musculus)
Guanine + H2O => Xanthine + NH4+ (Rattus norvegicus)
Guanine + H2O => Xanthine + NH4+ (Saccharomyces cerevisiae)
Guanine + H2O => Xanthine + NH4+ (Schizosaccharomyces pombe)
Guanine + H2O => Xanthine + NH4+ (Sus scrofa)
Guanine + H2O => Xanthine + NH4+ (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-07-17)
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