thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+

Stable Identifier
R-HSA-73616
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
reduction of thymine to form 5,6-Dihydrothymine
ReviewStatus
5/5
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thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
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Cytosolic dihydropyrimidine dehydrogenase catalyzes the reaction of thymine and NADPH + H+ to form 5,6-dihydrothymine and NADP+. The mechanism of the human reaction is inferred from that of the well-characterized pig enzyme (Yokota et al. 1994).
Literature References
PubMed ID Title Journal Year
8083224 cDNA cloning and chromosome mapping of human dihydropyrimidine dehydrogenase, an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria

McBride, OW, Schnackerz, KD, Podschun, B, Lin, K, Gonzalez, FJ, Fernandez-Salguero, P, Yokota, H, Furuya, H

J Biol Chem 1994
Participants
Input
Output
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as an event of
Catalyst Activity

dihydropyrimidine dehydrogenase (NADP+) activity of DPYD dimer [cytosol]

Physical Entity
DPYD dimer [cytosol] (Homo sapiens)
Activity
dihydropyrimidine dehydrogenase (NADP+) activity (GO:0017113)
Orthologous Events
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Bos taurus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Caenorhabditis elegans)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Canis familiaris)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Danio rerio)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Dictyostelium discoideum)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Drosophila melanogaster)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Gallus gallus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Mus musculus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Rattus norvegicus)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Sus scrofa)
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+ (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
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