Reactome | Release of eIF4E from the inactive eIF4E:4E-BP complex

Schema > Reaction > Entries

Release of eIF4E from the inactive eIF4E:4E-BP complex Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol
dbId	72622
displayName	Release of eIF4E from the inactive eIF4E:4E-BP complex
eventOf	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S - Homo sapiens
followingEvent	[Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex - Homo sapiens
input	[Complex:R-HSA-72581] eIF4E:4E-BP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:72623] Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Release of eIF4E from the inactive eIF4E:4E-BP complex
orthologousEvent	[Reaction:R-DDI-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Dictyostelium discoideum [Reaction:R-DME-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Drosophila melanogaster [Reaction:R-GGA-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Gallus gallus [Reaction:R-DRE-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Danio rerio [Reaction:R-SSC-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Sus scrofa [Reaction:R-BTA-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Bos taurus [Reaction:R-CFA-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Canis familiaris [Reaction:R-RNO-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Rattus norvegicus [Reaction:R-MMU-72622] Release of eIF4E from the inactive eIF4E:4E-BP complex - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-72578] EIF4E [cytosol] [EntityWithAccessionedSequence:R-HSA-72580] EIF4EBP1 [cytosol]
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-72622
summation	[Summation:72630] eIF4E gets released from the inactive eIF4E:4EBP complex. ...

Referrals

(hasEvent)	[Pathway:R-HSA-72662] Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
(precedingEvent)	[Reaction:R-HSA-72631] Formation of the cap-binding eIF4F complex