Reactome | G6PC hydrolyzes G6P to Glc and Pi (liver)

Schema > Reaction > Entries

G6PC hydrolyzes G6P to Glc and Pi (liver) Show undefined attributes

catalystActivity	[CatalystActivity:71824] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9643168] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
crossReference	[DatabaseIdentifier:9933542] RHEA:44905
dbId	71825
diseaseReaction	[FailedReaction:R-HSA-3274540] Defective G6PC does not hydrolyze glucose 6-phosphate - Homo sapiens
displayName	G6PC hydrolyzes G6P to Glc and Pi (liver)
eventOf	[Pathway:R-HSA-70263] Gluconeogenesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-198458] Efflux of Glc from the endoplasmic reticulum - Homo sapiens
input	[SimpleEntity:R-ALL-113782] G6P [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:198444] Genetic basis of glycogen storage disease type 1a: Prevalent mutations at the glucose-6-phosphatase locus [LiteratureReference:3266567] The catalytic center of glucose-6-phosphatase. HIS176 is the nucleophile forming the phosphohistidine-enzyme intermediate during catalysis [LiteratureReference:3274528] Mutations in the glucose-6-phosphatase gene that cause glycogen storage disease type 1a [LiteratureReference:3274546] Mutations in the glucose-6-phosphatase-alpha (G6PC) gene that cause type Ia glycogen storage disease
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	G6PC hydrolyzes G6P to Glc and Pi (liver) alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
orthologousEvent	[Reaction:R-GGA-353058] glucose 6-phosphate + H2O => glucose + phosphate - Gallus gallus [Reaction:R-DRE-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Danio rerio [Reaction:R-DME-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Drosophila melanogaster [Reaction:R-GGA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Gallus gallus [Reaction:R-XTR-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Xenopus tropicalis [Reaction:R-SSC-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Sus scrofa [Reaction:R-BTA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Bos taurus [Reaction:R-CFA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Canis familiaris [Reaction:R-RNO-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Rattus norvegicus [Reaction:R-MMU-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Mus musculus
output	[SimpleEntity:R-ALL-113780] Glc [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29
revised	[InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71825
summation	[Summation:71789] Glucose-6-phosphatase (G6PC) associated with the inner face ...
updateTrackers	[UpdateTracker:9787247] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v46:[modifyText] [UpdateTracker:9791758] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v26:[modifyText] [UpdateTracker:9787427] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v45:[add_removeLiteratureReference, modifyText] [UpdateTracker:9792259] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v22:[addLiteratureReference, modifyText] [UpdateTracker:9846823] Update Tracker - [Reaction:71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - v83:[modifyText] [UpdateTracker:9790075] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v35:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9787247] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v46:[modifyText] [UpdateTracker:9791758] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v26:[modifyText] [UpdateTracker:9787427] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v45:[add_removeLiteratureReference, modifyText] [UpdateTracker:9792259] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v22:[addLiteratureReference, modifyText] [UpdateTracker:9846823] Update Tracker - [Reaction:71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - v83:[modifyText] [UpdateTracker:9790075] Update Tracker - [Reaction:71825] G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver) - v35:[addLiteratureReference, modifyText]
(normalReaction)	[FailedReaction:R-HSA-3274540] Defective G6PC does not hydrolyze glucose 6-phosphate
(precedingEvent)	[BlackBoxEvent:R-HSA-198458] Efflux of Glc from the endoplasmic reticulum
(hasEvent)	[Pathway:R-HSA-70263] Gluconeogenesis

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