Reactome | G6PC hydrolyzes G6P to Glc and Pi (liver)

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G6PC hydrolyzes G6P to Glc and Pi (liver) Show undefined attributes

catalystActivity	[CatalystActivity:10335518] glucose-6-phosphatase activity of G6PC [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10335520
displayName	G6PC hydrolyzes G6P to Glc and Pi (liver)
eventOf	[Pathway:R-BTA-70263] Gluconeogenesis - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Homo sapiens
input	[SimpleEntity:R-ALL-113782] G6P [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	G6PC hydrolyzes G6P to Glc and Pi (liver) alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC - liver)
output	[SimpleEntity:R-ALL-113780] Glc [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113551] Pi [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-BTA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-71825
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-70263] Gluconeogenesis
(inferredTo)	[Reaction:R-HSA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver)

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