Reactome | Gluconeogenesis

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Gluconeogenesis Show undefined attributes

crossReference	[DatabaseIdentifier:12819595] BioModels Database:BIOMD0000000579
dbId	70263
deleted	[Deleted:8981599] Deletion of instance: 70153
displayName	Gluconeogenesis
doi	10.3180/R-HSA-70263.3
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-70326] Glucose metabolism - Homo sapiens
figure	[Figure:372927] /figures/Hs_gluconeogenesis.jpg
goBiologicalProcess	[GO_BiologicalProcess:15002] gluconeogenesis
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-70501] PC carboxylates PYR to OA - Homo sapiens [Reaction:R-HSA-70241] PCK1 phosphorylates OA to yield PEP - Homo sapiens [Reaction:R-HSA-372819] PCK2 phosphorylates OA to yield PEP - Homo sapiens [Reaction:R-HSA-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - Homo sapiens [Reaction:R-HSA-71445] PGAM dimers isomerise 2PG to 3PG - Homo sapiens [Reaction:R-HSA-70486] PGK complexes (PGK1,2) phosphorylate 3PG to form 1,3BPG - Homo sapiens [Reaction:R-HSA-70482] GAPDH tetramers reduce 1,3BPG to GA3P - Homo sapiens [Reaction:R-HSA-70481] TPI1 dimer isomerizes GA3P to DHAP - Homo sapiens [Reaction:R-HSA-71495] Aldolase tetramers convert GA3P and DHAP to F1,6PP - Homo sapiens [Reaction:R-HSA-70479] FBP tetramers hydrolyze F1,6PP to Fru(6)P - Homo sapiens [Reaction:R-HSA-70475] GPI dimer isomerizes Fru(6)P to G6P - Homo sapiens [Reaction:R-HSA-198513] SLC7A4 exchanges G6P for Pi across the ER membrane - Homo sapiens [Reaction:R-HSA-3257122] SLC37A1, SLC37A2 exchange G6P for Pi across the ER membrane - Homo sapiens [Reaction:R-HSA-71825] G6PC hydrolyzes G6P to Glc and Pi (liver) - Homo sapiens [Reaction:R-HSA-3266566] G6PC2 hydrolyzes G6P to form Glc and Pi (islet) - Homo sapiens [Reaction:R-HSA-3262512] G6PC3 hydrolyzes G6P to form Glc and Pi (ubiquitous) - Homo sapiens [BlackBoxEvent:R-HSA-198458] Efflux of Glc from the endoplasmic reticulum - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-03-29
literatureReference	[LiteratureReference:9815706] Biochemistry, Gluconeogenesis
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Gluconeogenesis
orthologousEvent	[Pathway:R-MMU-70263] Gluconeogenesis - Mus musculus [Pathway:R-RNO-70263] Gluconeogenesis - Rattus norvegicus [Pathway:R-CFA-70263] Gluconeogenesis - Canis familiaris [Pathway:R-BTA-70263] Gluconeogenesis - Bos taurus [Pathway:R-SSC-70263] Gluconeogenesis - Sus scrofa [Pathway:R-XTR-70263] Gluconeogenesis - Xenopus tropicalis [Pathway:R-GGA-70263] Gluconeogenesis - Gallus gallus [Pathway:R-DME-70263] Gluconeogenesis - Drosophila melanogaster [Pathway:R-CEL-70263] Gluconeogenesis - Caenorhabditis elegans [Pathway:R-DDI-70263] Gluconeogenesis - Dictyostelium discoideum [Pathway:R-SPO-70263] Gluconeogenesis - Schizosaccharomyces pombe [Pathway:R-SCE-70263] Gluconeogenesis - Saccharomyces cerevisiae [Pathway:R-PFA-70263] Gluconeogenesis - Plasmodium falciparum [Pathway:R-DRE-70263] Gluconeogenesis - Danio rerio
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2003-02-03
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:376870] Harris, RA, 2008-09-10 18:47:12 [InstanceEdit:9815859] Hill, David P, 2022-08-29 [InstanceEdit:9963240] D'Eustachio, Peter, 2025-08-13
revised	[InstanceEdit:377490] D'Eustachio, P, 2008-09-12 21:47:19 [InstanceEdit:9815860] D'Eustachio, Peter, 2022-08-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-70263
summation	[Summation:71614] Gluconeogenesis converts mitochondrial pyruvate to cytosolic...
updateTrackers	[UpdateTracker:9790406] Update Tracker - [Pathway:70263] Gluconeogenesis - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9791763] Update Tracker - [Pathway:70263] Gluconeogenesis - v26:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9792258] Update Tracker - [Pathway:70263] Gluconeogenesis - v22:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9781415] Update Tracker - [Pathway:70263] Gluconeogenesis - v61:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9775379] Update Tracker - [Pathway:70263] Gluconeogenesis - v79:[updateContainedRLE] [UpdateTracker:9786537] Update Tracker - [Pathway:70263] Gluconeogenesis - v49:[updateContainedRLE] [UpdateTracker:9846961] Update Tracker - [Pathway:70263] Gluconeogenesis - v82:[updateContainedRLE] [UpdateTracker:9846945] Update Tracker - [Pathway:70263] Gluconeogenesis - v83:[add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9864195] Update Tracker - [Pathway:70263] Gluconeogenesis - v88:[removeHasEvent, updateContainedRLE] [UpdateTracker:9790900] Update Tracker - [Pathway:70263] Gluconeogenesis - v32:[removeHasEvent, updateContainedRLE] [UpdateTracker:9791609] Update Tracker - [Pathway:70263] Gluconeogenesis - v28:[updateContainedRLE] [UpdateTracker:9789523] Update Tracker - [Pathway:70263] Gluconeogenesis - v38:[addLiteratureReference, modifyText] [UpdateTracker:9781612] Update Tracker - [Pathway:70263] Gluconeogenesis - v60:[updateContainedRLE] [UpdateTracker:9846631] Update Tracker - [Pathway:70263] Gluconeogenesis - v84:[updateContainedRLE]

Referrals

(hasEvent)	[Pathway:R-HSA-70326] Glucose metabolism
(replacementInstances)	[Deleted:8981599] Deletion of instance: 70153
(updatedInstance)	[UpdateTracker:9790406] Update Tracker - [Pathway:70263] Gluconeogenesis - v33:[addHasEvent, updateContainedRLE] [UpdateTracker:9791763] Update Tracker - [Pathway:70263] Gluconeogenesis - v26:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9792258] Update Tracker - [Pathway:70263] Gluconeogenesis - v22:[add_removeHasEvent, modifyText, updateContainedRLE] [UpdateTracker:9781415] Update Tracker - [Pathway:70263] Gluconeogenesis - v61:[add_removeHasEvent, updateContainedRLE] [UpdateTracker:9775379] Update Tracker - [Pathway:70263] Gluconeogenesis - v79:[updateContainedRLE] [UpdateTracker:9786537] Update Tracker - [Pathway:70263] Gluconeogenesis - v49:[updateContainedRLE] [UpdateTracker:9846961] Update Tracker - [Pathway:70263] Gluconeogenesis - v82:[updateContainedRLE] [UpdateTracker:9846945] Update Tracker - [Pathway:70263] Gluconeogenesis - v83:[add_removeLiteratureReference, modifyText, updateContainedRLE] [UpdateTracker:9864195] Update Tracker - [Pathway:70263] Gluconeogenesis - v88:[removeHasEvent, updateContainedRLE] [UpdateTracker:9790900] Update Tracker - [Pathway:70263] Gluconeogenesis - v32:[removeHasEvent, updateContainedRLE] [UpdateTracker:9791609] Update Tracker - [Pathway:70263] Gluconeogenesis - v28:[updateContainedRLE] [UpdateTracker:9789523] Update Tracker - [Pathway:70263] Gluconeogenesis - v38:[addLiteratureReference, modifyText] [UpdateTracker:9781612] Update Tracker - [Pathway:70263] Gluconeogenesis - v60:[updateContainedRLE] [UpdateTracker:9846631] Update Tracker - [Pathway:70263] Gluconeogenesis - v84:[updateContainedRLE]

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