Reactome | q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

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q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71128] 6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644031] 6,7-dihydropteridine reductase activity of QDPR dimer [cytosol] Structure and expression of human dihydropteridine reductase
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667815] RHEA:32253 [DatabaseIdentifier:9929218] RHEA:32253
dbId	71130
displayName	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-8964208] Phenylalanine metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-71129] qDHB [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71121] Structure and expression of human dihydropteridine reductase [LiteratureReference:517451] The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)
orthologousEvent	[Reaction:R-RNO-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Rattus norvegicus [Reaction:R-DDI-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Dictyostelium discoideum [Reaction:R-CEL-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Caenorhabditis elegans [Reaction:R-DME-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Drosophila melanogaster [Reaction:R-GGA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Gallus gallus [Reaction:R-XTR-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Xenopus tropicalis [Reaction:R-DRE-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Danio rerio [Reaction:R-SSC-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Sus scrofa [Reaction:R-BTA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Bos taurus [Reaction:R-CFA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Canis familiaris [Reaction:R-MMU-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Mus musculus
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
precedingEvent	[Reaction:R-HSA-71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71130
summation	[Summation:179128] Cytosolic dihydropteridine reductase (QDPR) catalyzes the re...
updateTrackers	[UpdateTracker:9790936] Update Tracker - [Reaction:71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - v32:[add_removeLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790936] Update Tracker - [Reaction:71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - v32:[add_removeLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-8964208] Phenylalanine metabolism
(precedingEvent)	[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr