Reactome | q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+

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q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ Show undefined attributes

catalystActivity	[CatalystActivity:10561863] 6,7-dihydropteridine reductase activity of QDPR dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10561865
displayName	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
eventOf	[Pathway:R-DRE-8964208] Phenylalanine metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Danio rerio
inferredFrom	[Reaction:R-HSA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-71129] qDHB [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ (6R)-L-erythro-6,7-dihydrobiopterin + H(+) + NADH => (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + NAD(+)
output	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
precedingEvent	[Reaction:R-DRE-71146] 4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-71130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-8964208] Phenylalanine metabolism
(inferredTo)	[Reaction:R-HSA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+
(precedingEvent)	[Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr

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