Reactome | HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P

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HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P Show undefined attributes

catalystActivity	[CatalystActivity:10104374] glucokinase activity of glucokinase and hexokinases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10104376
displayName	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P
eventOf	[Pathway:R-RNO-70171] Glycolysis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9638127] PGM1:Mg2+ isomerises G6P to G1P - Rattus norvegicus [Reaction:R-RNO-70377] G6PD multimers dehydrogenate G6P - Rattus norvegicus [Reaction:R-RNO-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP - Rattus norvegicus [Reaction:R-RNO-70471] GPI dimer isomerizes G6P - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-70113] Glc [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P alpha-D-Glucose + ATP => alpha-D-glucose 6-phosphate + ADP
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-30537] G6P [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-70420
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-RNO-9638127] PGM1:Mg2+ isomerises G6P to G1P [Reaction:R-RNO-70377] G6PD multimers dehydrogenate G6P [Reaction:R-RNO-8955760] PGM2L1:Mg2+ phosphorylates G6P to G1,6BP [Reaction:R-RNO-70471] GPI dimer isomerizes G6P
(hasEvent)	[Pathway:R-RNO-70171] Glycolysis
(inferredTo)	[Reaction:R-HSA-70420] HK1,2,3,GCK,HKDC1 phosphorylate Glc to form G6P

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