Reactome | GALM converts beta-D-GAL to alpha-D-GAL

Schema > Reaction > Entries

GALM converts beta-D-GAL to alpha-D-GAL Show undefined attributes

authored	[InstanceEdit:9931930] Rothfels, Karen, 2024-12-13
catalystActivity	[CatalystActivity:9931854] aldose 1-epimerase activity of GALM [cytosol]
catalystActivityReference	[CatalystActivityReference:9931847] aldose 1-epimerase activity of GALM [cytosol] Identification and characterisation of human aldose 1-epimerase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9931849] Rothfels, Karen, 2024-12-13
crossReference	[DatabaseIdentifier:12667689] RHEA:28677 [DatabaseIdentifier:9936195] RHEA:28677
dbId	9931853
diseaseReaction	[FailedReaction:R-HSA-9931926] Defective GALM doesn't convert beta-D-GAL to alpha-D-GAL - Homo sapiens
displayName	GALM converts beta-D-GAL to alpha-D-GAL
edited	[InstanceEdit:9931930] Rothfels, Karen, 2024-12-13
eventOf	[Pathway:R-HSA-70370] Galactose catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9931850] AKR1B1 reduces galactose to galactitol - Homo sapiens [Reaction:R-HSA-70355] GALK1 phosphorylates Gal to Gal1P - Homo sapiens
input	[SimpleEntity:R-ALL-9931855] beta-D-Gal [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6787690] Identification and characterisation of human aldose 1-epimerase [LiteratureReference:9931813] Molecular structure of human galactose mutarotase [LiteratureReference:199732] Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	GALM converts beta-D-GAL to alpha-D-GAL beta-D-galactose=>alpha-D-galactose
orthologousEvent	[Reaction:R-MMU-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Mus musculus [Reaction:R-SCE-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Saccharomyces cerevisiae [Reaction:R-CEL-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Caenorhabditis elegans [Reaction:R-DME-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Drosophila melanogaster [Reaction:R-GGA-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Gallus gallus [Reaction:R-XTR-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Xenopus tropicalis [Reaction:R-DRE-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Danio rerio [Reaction:R-SSC-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Sus scrofa [Reaction:R-BTA-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Bos taurus [Reaction:R-CFA-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Canis familiaris [Reaction:R-RNO-9931853] GALM converts beta-D-GAL to alpha-D-GAL - Rattus norvegicus
output	[SimpleEntity:R-ALL-9931851] alpha-D-Gal [cytosol]
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9936506] D'Eustachio, Peter, 2025-01-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9931853
summation	[Summation:9931852] GALM catalyzes the interconversion of alpha- and beta-D-hexo...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9931926] Defective GALM doesn't convert beta-D-GAL to alpha-D-GAL
(precedingEvent)	[Reaction:R-HSA-9931850] AKR1B1 reduces galactose to galactitol [Reaction:R-HSA-70355] GALK1 phosphorylates Gal to Gal1P
(hasEvent)	[Pathway:R-HSA-70370] Galactose catabolism