Reactome | p53-Dependent G1 DNA Damage Response

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p53-Dependent G1 DNA Damage Response Show undefined attributes

created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10910578
displayName	p53-Dependent G1 DNA Damage Response
eventOf	[Pathway:R-DME-69580] p53-Dependent G1/S DNA damage checkpoint - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:22659] DNA damage response, signal transduction by p53 class mediator
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-DME-69541] Stabilization of p53 - Drosophila melanogaster [Reaction:R-DME-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Drosophila melanogaster [Reaction:R-DME-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Drosophila melanogaster
inferredFrom	[Pathway:R-HSA-69563] p53-Dependent G1 DNA Damage Response - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	p53-Dependent G1 DNA Damage Response
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:56210] Drosophila melanogaster
stId	R-DME-69563
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-69580] p53-Dependent G1/S DNA damage checkpoint
(inferredTo)	[Pathway:R-HSA-69563] p53-Dependent G1 DNA Damage Response

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