Reactome | TBC1D20 binds RAB1:GTP

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TBC1D20 binds RAB1:GTP Show undefined attributes

authored	[InstanceEdit:6814838] Rothfels, Karen, 2015-11-27
category	binding
compartment	[Compartment:6791047] endoplasmic reticulum-Golgi intermediate compartment membrane
created	[InstanceEdit:6814829] Rothfels, Karen, 2015-11-27
dbId	6814831
displayName	TBC1D20 binds RAB1:GTP
edited	[InstanceEdit:6814838] Rothfels, Karen, 2015-11-27
eventOf	[Pathway:R-HSA-204005] COPII-mediated vesicle transport - Homo sapiens
followingEvent	[Reaction:R-HSA-6814833] TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP - Homo sapiens
input	[Complex:R-HSA-6807799] RAB1:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] [EntityWithAccessionedSequence:R-HSA-6814813] TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6814823] Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells [LiteratureReference:6814826] Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TBC1D20 binds RAB1:GTP
orthologousEvent	[Reaction:R-BTA-6814831] TBC1D20 binds RAB1:GTP - Bos taurus [Reaction:R-PFA-6814831] TBC1D20 binds RAB1:GTP - Plasmodium falciparum [Reaction:R-SCE-6814831] TBC1D20 binds RAB1:GTP - Saccharomyces cerevisiae [Reaction:R-SPO-6814831] TBC1D20 binds RAB1:GTP - Schizosaccharomyces pombe [Reaction:R-DDI-6814831] TBC1D20 binds RAB1:GTP - Dictyostelium discoideum [Reaction:R-CEL-6814831] TBC1D20 binds RAB1:GTP - Caenorhabditis elegans [Reaction:R-DME-6814831] TBC1D20 binds RAB1:GTP - Drosophila melanogaster [Reaction:R-DRE-6814831] TBC1D20 binds RAB1:GTP - Danio rerio [Reaction:R-CFA-6814831] TBC1D20 binds RAB1:GTP - Canis familiaris [Reaction:R-RNO-6814831] TBC1D20 binds RAB1:GTP - Rattus norvegicus [Reaction:R-MMU-6814831] TBC1D20 binds RAB1:GTP - Mus musculus
output	[Complex:R-HSA-6814832] RAB1:GTP:TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6814172] Gillespie, Marc E, 2015-11-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6814831
summation	[Summation:6814830] TBC1D20 was identified as a GTPase activating protein for RA...

Referrals

(precedingEvent)	[Reaction:R-HSA-6814833] TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP
(hasEvent)	[Pathway:R-HSA-204005] COPII-mediated vesicle transport