Reactome | TBC1D20 binds RAB1:GTP

TBC1D20 binds RAB1:GTP

Stable Identifier

R-HSA-6814831

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        TBC1D20 binds RAB1:GTP (Homo sapiens)

General

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TBC1D20 was identified as a GTPase activating protein for RAB1 that stimulates basal GTP hydrolysis by more than 5 orders of magnitude (Haas et al, 2007; Fuchs et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
17684057	Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells Haas, AK, Yoshimura, S, Stephens, DJ, Preisinger, C, Fuchs, E, Barr, FA	J. Cell. Sci.	2007
17562788	Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways Fuchs, E, Haas, AK, Spooner, RA, Yoshimura, S, Lord, JM, Barr, FA	J. Cell Biol.	2007