Reactome | NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN

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NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN Show undefined attributes

authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
catalystActivity	[CatalystActivity:6814679] ATP hydrolysis activity of STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
category	transition
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6814685] Rothfels, Karen, 2015-11-27
dbId	6814683
displayName	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
eventOf	[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6814660] STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5688473] Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles [LiteratureReference:5688485] An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion [LiteratureReference:5688502] Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion [LiteratureReference:5688488] Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles [LiteratureReference:5688492] Multiple binding proteins suggest diverse functions for the N-ethylmaleimide sensitive factor [LiteratureReference:5688493] NSF N-terminal domain crystal structure: models of NSF function [LiteratureReference:5688498] Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF) [LiteratureReference:5688193] Membrane fusion: grappling with SNARE and SM proteins
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
orthologousEvent	[Reaction:R-GGA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Gallus gallus [Reaction:R-BTA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Bos taurus [Reaction:R-RNO-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Rattus norvegicus [Reaction:R-MMU-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2193131] NSF hexamer [cytosol] 3 × [CandidateSet:R-HSA-5694313] SNAPs [cytosol] [EntityWithAccessionedSequence:R-HSA-6811002] STX16 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-HSA-6811007] STX6 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-HSA-6811021] VAMP4 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-HSA-6813927] VTI1A [trans-Golgi network membrane]
precedingEvent	[Reaction:R-HSA-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6814683
summation	[Summation:5694378] NSF-dependent hydrolysis of ATP is required to disassociate ...

Referrals

(hasEvent)

[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network

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