Reactome | cis-SNARE binds SNAPs and NSF hexamer at the TGN

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cis-SNARE binds SNAPs and NSF hexamer at the TGN Show undefined attributes

authored	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
category	binding
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:6814685] Rothfels, Karen, 2015-11-27
dbId	6814684
displayName	cis-SNARE binds SNAPs and NSF hexamer at the TGN
edited	[InstanceEdit:6809025] Rothfels, Karen, 2015-11-09
eventOf	[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network - Homo sapiens
followingEvent	[Reaction:R-HSA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Homo sapiens
input	[Complex:R-HSA-2193131] NSF hexamer [cytosol] 3 × [CandidateSet:R-HSA-5694313] SNAPs [cytosol] [Complex:R-HSA-6814656] STX6:STX16:VTI1A:VAMP4 [trans-Golgi network membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5688473] Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles [LiteratureReference:5688461] A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion [LiteratureReference:5689380] SNAREs--engines for membrane fusion [LiteratureReference:5688193] Membrane fusion: grappling with SNARE and SM proteins
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	cis-SNARE binds SNAPs and NSF hexamer at the TGN
orthologousEvent	[Reaction:R-SCE-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Saccharomyces cerevisiae [Reaction:R-SPO-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Schizosaccharomyces pombe [Reaction:R-DDI-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Dictyostelium discoideum [Reaction:R-DME-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Drosophila melanogaster [Reaction:R-GGA-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Gallus gallus [Reaction:R-SSC-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Sus scrofa [Reaction:R-BTA-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Bos taurus [Reaction:R-CFA-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Canis familiaris [Reaction:R-RNO-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Rattus norvegicus [Reaction:R-MMU-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Mus musculus
output	[Complex:R-HSA-6814660] STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
precedingEvent	[BlackBoxEvent:R-HSA-6814682] Fusion of early-endosome derived vesicles at the TGN - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855182] Gillespie, Marc E, 2016-02-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6814684
summation	[Summation:6811276] After membrane fusion, the 4-membered cis-SNARE complex is d...

Referrals

(precedingEvent)	[Reaction:R-HSA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
(hasEvent)	[Pathway:R-HSA-6811440] Retrograde transport at the Trans-Golgi-Network