Reactome | NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN

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NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN Show undefined attributes

catalystActivity	[CatalystActivity:10074568] ATP hydrolysis activity of STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
category	transition
compartment	[Compartment:263163] trans-Golgi network membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10074570
displayName	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
eventOf	[Pathway:R-MMU-6811440] Retrograde transport at the Trans-Golgi-Network - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-6814660] STX6:STX16:VTI1A:VAMP4:NSF hexamer:3xSNAPs [trans-Golgi network membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2193131] NSF hexamer [cytosol] 3 × [CandidateSet:R-MMU-5694313] SNAPs [cytosol] [EntityWithAccessionedSequence:R-MMU-6811002] Stx16 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-MMU-6811007] Stx6 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-MMU-6811021] Vamp4 [trans-Golgi network membrane] [EntityWithAccessionedSequence:R-MMU-6813927] Vti1a [trans-Golgi network membrane]
precedingEvent	[Reaction:R-MMU-6814684] cis-SNARE binds SNAPs and NSF hexamer at the TGN - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6814683
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6811440] Retrograde transport at the Trans-Golgi-Network
(inferredTo)	[Reaction:R-HSA-6814683] NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN

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