Reactome | PI3P is dephosphorylated to PI by MTMR2:SBF1

Schema > Reaction > Entries

PI3P is dephosphorylated to PI by MTMR2:SBF1 Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:6809771] phosphatidylinositol-3-phosphate phosphatase activity of MTMR2:SBF1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6809773] Orlic-Milacic, Marija, 2015-11-12
dbId	6809777
displayName	PI3P is dephosphorylated to PI by MTMR2:SBF1
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-5676030] PI3P [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809750] Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase [LiteratureReference:6809762] Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module [LiteratureReference:6809759] SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	PI3P is dephosphorylated to PI by MTMR2:SBF1
orthologousEvent	[Reaction:R-SCE-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Saccharomyces cerevisiae [Reaction:R-SPO-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Schizosaccharomyces pombe [Reaction:R-DDI-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Dictyostelium discoideum [Reaction:R-CEL-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Caenorhabditis elegans [Reaction:R-DME-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Drosophila melanogaster [Reaction:R-GGA-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Gallus gallus [Reaction:R-DRE-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Danio rerio [Reaction:R-SSC-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Sus scrofa [Reaction:R-BTA-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Bos taurus [Reaction:R-CFA-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Canis familiaris [Reaction:R-RNO-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Rattus norvegicus [Reaction:R-MMU-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-426639] PI [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-6809764] SBF1 binds MTMR2 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809777
summation	[Summation:6809776] Binding to SBF1 (MTMR5) increases phosphatidylinositol-3-pho...

Referrals

(hasEvent)

[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane

Cite Us!