Reactome | SBF1 binds MTMR2

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SBF1 binds MTMR2 Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:9949585] protein-membrane adaptor activity of SBF1 [endoplasmic reticulum membrane]
catalystActivityReference	[CatalystActivityReference:9949587] protein-membrane adaptor activity of SBF1 [endoplasmic reticulum membrane] Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6809751] Orlic-Milacic, Marija, 2015-11-12
dbId	6809764
displayName	SBF1 binds MTMR2
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 - Homo sapiens [Reaction:R-HSA-6809778] PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1604662] MTMR2 [cytosol] [EntityWithAccessionedSequence:R-HSA-6809747] SBF1 [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809762] Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module [LiteratureReference:6809750] Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase [LiteratureReference:6809759] SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	SBF1 binds MTMR2
orthologousEvent	[Reaction:R-SCE-6809764] SBF1 binds MTMR2 - Saccharomyces cerevisiae [Reaction:R-SPO-6809764] SBF1 binds MTMR2 - Schizosaccharomyces pombe [Reaction:R-DDI-6809764] SBF1 binds MTMR2 - Dictyostelium discoideum [Reaction:R-CEL-6809764] SBF1 binds MTMR2 - Caenorhabditis elegans [Reaction:R-DME-6809764] SBF1 binds MTMR2 - Drosophila melanogaster [Reaction:R-GGA-6809764] SBF1 binds MTMR2 - Gallus gallus [Reaction:R-DRE-6809764] SBF1 binds MTMR2 - Danio rerio [Reaction:R-SSC-6809764] SBF1 binds MTMR2 - Sus scrofa [Reaction:R-BTA-6809764] SBF1 binds MTMR2 - Bos taurus [Reaction:R-CFA-6809764] SBF1 binds MTMR2 - Canis familiaris [Reaction:R-RNO-6809764] SBF1 binds MTMR2 - Rattus norvegicus [Reaction:R-MMU-6809764] SBF1 binds MTMR2 - Mus musculus
output	[Complex:R-HSA-6809761] MTMR2:SBF1 [endoplasmic reticulum membrane]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10 [InstanceEdit:9962972] Hill, David P, 2025-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809764
summation	[Summation:6809756] MTMR2 forms a heterodimer with SBF1 (MTMR5), an enzymaticall...
updateTrackers	[UpdateTracker:9953659] Update Tracker - [Reaction:6809764] SBF1 binds MTMR2 - v93:[removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9953659] Update Tracker - [Reaction:6809764] SBF1 binds MTMR2 - v93:[removeCatalystActivity]
(precedingEvent)	[Reaction:R-HSA-6809777] PI3P is dephosphorylated to PI by MTMR2:SBF1 [Reaction:R-HSA-6809778] PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1
(hasEvent)	[Pathway:R-HSA-1483248] Synthesis of PIPs at the ER membrane

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