Reactome | PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane

Schema > Reaction > Entries

PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane Show undefined attributes

authored	[InstanceEdit:6809880] Orlic-Milacic, Marija, 2015-11-13
catalystActivity	[CatalystActivity:6809317] phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of MTMR6:MTMR9,MTMR8:MTMR9 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:6809319] Orlic-Milacic, Marija, 2015-11-10
crossReference	[DatabaseIdentifier:12667424] RHEA:39019
dbId	6809320
displayName	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane
edited	[InstanceEdit:8959448] Orlic-Milacic, Marija, 2017-01-25
eventOf	[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-1806224] PI(3,5)P2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6809251] Myotubularin-related protein (MTMR) 9 determines the enzymatic activity, substrate specificity, and role in autophagy of MTMR8 [LiteratureReference:6809243] MTMR9 increases MTMR6 enzyme activity, stability, and role in apoptosis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane
orthologousEvent	[Reaction:R-CEL-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Caenorhabditis elegans [Reaction:R-DME-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Drosophila melanogaster [Reaction:R-GGA-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Gallus gallus [Reaction:R-DRE-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Danio rerio [Reaction:R-SSC-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Sus scrofa [Reaction:R-BTA-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Bos taurus [Reaction:R-CFA-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Canis familiaris [Reaction:R-RNO-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Rattus norvegicus [Reaction:R-MMU-6809320] PI(3,5)P2 is dephosphorylated to PI5P by MTMR9-bound MTMR6 or MTMR8 at the plasma membrane - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [SimpleEntity:R-ALL-1806240] PI5P [plasma membrane]
precedingEvent	[Reaction:R-HSA-1676134] PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8959443] Rush, Mark G, 2017-01-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6809320
summation	[Summation:6809488] Formation of a complex with MTMR9 results in a 30-fold incre...

Referrals

(hasEvent)

[Pathway:R-HSA-1660499] Synthesis of PIPs at the plasma membrane