Reactome | PTEN undergoes monoubiquitination

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PTEN undergoes monoubiquitination Show undefined attributes

authored	[InstanceEdit:6807104] Orlic-Milacic, Marija, 2015-10-29
catalystActivity	[CatalystActivity:6807253] ubiquitin protein ligase activity of XIAP,NEDD4 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6807104] Orlic-Milacic, Marija, 2015-10-29
dbId	6807106
displayName	PTEN undergoes monoubiquitination
edited	[InstanceEdit:9005630] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8948747] Regulation of PTEN localization - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6807105] Monoubiquitinated PTEN translocates to the nucleus - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-199420] PTEN [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5690089] Ubiquitination regulates PTEN nuclear import and tumor suppression [LiteratureReference:6807128] X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	PTEN undergoes monoubiquitination
orthologousEvent	[Reaction:R-DME-6807106] PTEN undergoes monoubiquitination - Drosophila melanogaster [Reaction:R-GGA-6807106] PTEN undergoes monoubiquitination - Gallus gallus [Reaction:R-DRE-6807106] PTEN undergoes monoubiquitination - Danio rerio [Reaction:R-SSC-6807106] PTEN undergoes monoubiquitination - Sus scrofa [Reaction:R-BTA-6807106] PTEN undergoes monoubiquitination - Bos taurus [Reaction:R-CFA-6807106] PTEN undergoes monoubiquitination - Canis familiaris [Reaction:R-RNO-6807106] PTEN undergoes monoubiquitination - Rattus norvegicus [Reaction:R-MMU-6807106] PTEN undergoes monoubiquitination - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-6807247] MonoUb-K13,K289-PTEN [cytosol]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8948085] Leslie, Nicholas, 2016-09-30 [InstanceEdit:8948084] Kriplani, Nisha, 2016-09-30 [InstanceEdit:8948082] Carracedo, Arkaitz, 2016-08-11 [InstanceEdit:8948087] Salmena, Leonardo, 2016-08-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6807106
summation	[Summation:6807251] When present at low levels in the cell, the E3 ubiquitin lig...
updateTrackers	[UpdateTracker:9778596] Update Tracker - [Reaction:6807106] PTEN undergoes monoubiquitination - v68:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9778596] Update Tracker - [Reaction:6807106] PTEN undergoes monoubiquitination - v68:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-8948747] Regulation of PTEN localization
(precedingEvent)	[BlackBoxEvent:R-HSA-6807105] Monoubiquitinated PTEN translocates to the nucleus