When present at low levels in the cell, the E3 ubiquitin lig...

created [InstanceEdit:6807252] Orlic-Milacic, Marija, 2015-10-30
dbId 6807251
displayName When present at low levels in the cell, the E3 ubiquitin lig...
modified [InstanceEdit:6807300] Orlic-Milacic, Marija, 2015-10-30
schemaClass Summation
text When present at low levels in the cell, the E3 ubiquitin ligase XIAP monoubiquitinates PTEN (Van Themsche et al. 2009). NEDD4 (NEDD4-1) can also monoubiquitinate PTEN (Trotman et al. 2007). Monoubiquitination of PTEN on at least lysine residues K13 and K289 causes translocation of PTEN from the cytosol to the nucleus (Trotman et al. 2007, Van Themsche et al. 2009).
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