NR2E1 associated with transcription repressors binds PTEN promoter

Stable Identifier
Reaction [binding]
Homo sapiens
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NR2E1 (TLX) associated with transcription repressors binds the evolutionarily conserved TLX consensus site in the PTEN promoter. NR2E1 inhibits PTEN transcription by associating with various transcriptional repressors, probably in a cell type or tissue specific manner. PTEN transcription is inhibited when NR2E1 forms a complex with ATN1 (atrophin-1) (Zhang et al. 2006, Yokoyama et al. 2008), KDM1A (LSD1) histone methyltransferase containing CoREST complex (Yokoyama et al. 2008), or histone deacetylases HDAC3, HDAC5 or HDAC7 (Sun et al. 2007).

Literature References
PubMed ID Title Journal Year
18391013 Transrepressive function of TLX requires the histone demethylase LSD1

Schüle, R, Takezawa, S, Yokoyama, A, Kitagawa, H, Kato, S

Mol. Cell. Biol. 2008
17873065 Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation

Sun, G, Shi, Y, Evans, RM, Yu, RT

Proc. Natl. Acad. Sci. U.S.A. 2007
16702404 Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

Zhang, CL, Zou, Y, Gage, FH, Evans, RM, Yu, RT

Genes Dev. 2006
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