Reactome | Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

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Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Show undefined attributes

authored	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6807046] D'Eustachio, Peter, 2015-10-28
dbId	6807062
displayName	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
edited	[InstanceEdit:6807519] D'Eustachio, Peter, 2015-11-02
eventOf	[Pathway:R-HSA-191273] Cholesterol biosynthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:20521] cholesterol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9755937] DHCR24 reduces LAN to 24,25-dhLAN - Homo sapiens [Reaction:R-HSA-9947148] CYP51A1 14-demethylates 24,25-dhLAN to 4,4-diMeCholesta-8,14-dien-3-ol - Homo sapiens [Reaction:R-HSA-9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol - Homo sapiens [Reaction:R-HSA-9947203] MSMO1 oxidizes 4,4-diMe-5-cholest-8-en-3-ol to 4a-carboxy-4b-me-5a-cholest-8-en-3b-ol - Homo sapiens [Reaction:R-HSA-9945822] NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol - Homo sapiens [Reaction:R-HSA-9945784] HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol - Homo sapiens [Reaction:R-HSA-9947207] MSMO1 oxidizes 4a-me-5a-cholest-8-en-3b-ol to 4a-carboxy-5a-cholest-8-ene-3b-ol - Homo sapiens [Reaction:R-HSA-9945787] NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one - Homo sapiens [Reaction:R-HSA-9945804] HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6807051] Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol [LiteratureReference:6807060] Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Cholesterol biosynthesis via lathosterol (Kandutsch-Russell pathway)
orthologousEvent	[Pathway:R-BTA-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Bos taurus [Pathway:R-SCE-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Saccharomyces cerevisiae [Pathway:R-SPO-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Schizosaccharomyces pombe [Pathway:R-DDI-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Dictyostelium discoideum [Pathway:R-CEL-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Caenorhabditis elegans [Pathway:R-GGA-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Gallus gallus [Pathway:R-XTR-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Xenopus tropicalis [Pathway:R-DRE-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Danio rerio [Pathway:R-SSC-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Sus scrofa [Pathway:R-CFA-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Canis familiaris [Pathway:R-RNO-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Rattus norvegicus [Pathway:R-MMU-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Mus musculus
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6807520] Jassal, Bijay, 2015-11-02 [InstanceEdit:9953269] Hill, David P, 2025-05-30 [InstanceEdit:9969910] Hill, David P, 2025-10-24
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6807062
summation	[Summation:6807044] The transformation of zymosterol into cholesterol can follow...
updateTrackers	[UpdateTracker:9971917] Update Tracker - [Pathway:6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - v95:[add_removeHasEvent] [UpdateTracker:9953630] Update Tracker - [Pathway:6807062] Cholesterol biosynthesis via lathosterol - v93:[removeHasEvent]

Referrals

(updatedInstance)	[UpdateTracker:9971917] Update Tracker - [Pathway:6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - v95:[add_removeHasEvent] [UpdateTracker:9953630] Update Tracker - [Pathway:6807062] Cholesterol biosynthesis via lathosterol - v93:[removeHasEvent]
(hasEvent)	[Pathway:R-HSA-191273] Cholesterol biosynthesis

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