Cholesterol biosynthesis via lathosterol

Stable Identifier
R-HSA-6807062
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Kandutsch-Russell pathway
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The transformation of zymosterol into cholesterol can follow either of routes, one in which reduction of the double bond in the isooctyl side chain is the final step (cholesterol synthesis via desmosterol, also known as the Bloch pathway) and one in which this reduction is the first step (cholesterol biosynthesis via lathosterol, also known as the Kandutsch-Russell pathway). The former pathway is prominent in the liver and many other tissues while the latter is prominent in skin, where it may serve as the source of the 7-dehydrocholesterol that is the starting point for the synthesis of D vitamins (Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References
PubMed ID Title Journal Year
26114596 Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC

Elife 2015
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Kandutsch, AA, Russell, AE

J. Biol. Chem. 1960
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created