Reactome | Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

Stable Identifier

R-HSA-6807062

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

Cholesterol biosynthesis via lathosterol (Kandutsch-Russell pathway)

ReviewStatus

5/5

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Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

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The transformation of zymosterol into cholesterol can follow either of routes, one in which reduction of the double bond in the isooctyl side chain is the final step (cholesterol synthesis via desmosterol, also known as the Bloch pathway) and one in which this reduction is the first step (cholesterol biosynthesis via lathosterol, also known as the Kandutsch-Russell pathway). The former pathway is prominent in the liver and many other tissues while the latter is prominent in skin, where it may serve as the source of the 7-dehydrocholesterol that is the starting point for the synthesis of D vitamins (Kandutsch & Russell 1960; Mitsche et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Kandutsch, AA, Russell, AE	J. Biol. Chem.	1960
26114596	Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways Mitsche, MA, McDonald, JG, Hobbs, HH, Cohen, JC	Elife	2015