Reactome | Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

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Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225377
displayName	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)
eventOf	[Pathway:R-RNO-191273] Cholesterol biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20521] cholesterol biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9755937] DHCR24 reduces LAN to 24,25-dhLAN - Rattus norvegicus [Reaction:R-RNO-9946140] TM7SF2 reduces 4,4-diMeCholesta-8,14-dien-3-ol to 4,4-diMe5-cholest-8-en-3-ol - Rattus norvegicus [Reaction:R-RNO-9945822] NSDHL decarboxylates 4a-carboxy-4b-methyl-5a-cholest-8-en-3b-ol to 4a-methyl-5a-cholest-8-en-3b-ol - Rattus norvegicus [Reaction:R-RNO-9945784] HSD17B7 reduces 4a-methyl-5a-cholest-8-en-3-one to 4a-methyl-5a-cholest-8-en-3b-ol - Rattus norvegicus [Reaction:R-RNO-9945787] NSDHL decarboxylates 4a-carboxy-5a-cholest-8-ene-3b-ol to 5a-cholest-8-en-3-one - Rattus norvegicus [Reaction:R-RNO-9945804] HSD17B7 reduces 5a-cholest-8-en-3-one to ZYMSTNL - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway) Cholesterol biosynthesis via lathosterol (Kandutsch-Russell pathway)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6807062
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-191273] Cholesterol biosynthesis
(inferredTo)	[Pathway:R-HSA-6807062] Zymostenol biosynthesis via lathosterol (Kandutsch-Russell pathway)

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