Reactome | CYB5Rs reduce MetHb to HbA

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CYB5Rs reduce MetHb to HbA Show undefined attributes

authored	[InstanceEdit:6806828] Jassal, Bijay, 2015-10-26
catalystActivity	[CatalystActivity:6806867] cytochrome-b5 reductase activity, acting on NAD(P)H of CYB5Rs [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:6806828] Jassal, Bijay, 2015-10-26
dbId	6806831
displayName	CYB5Rs reduce MetHb to HbA
edited	[InstanceEdit:6806828] Jassal, Bijay, 2015-10-26
eventOf	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen - Homo sapiens
input	[Complex:R-HSA-9033251] MetHb [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6806857] Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells [LiteratureReference:6806871] Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa [LiteratureReference:6806866] NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CYB5Rs reduce MetHb to HbA
orthologousEvent	[Reaction:R-GGA-6806831] CYB5Rs reduce MetHb to HbA - Gallus gallus [Reaction:R-XTR-6806831] CYB5Rs reduce MetHb to HbA - Xenopus tropicalis [Reaction:R-SSC-6806831] CYB5Rs reduce MetHb to HbA - Sus scrofa [Reaction:R-BTA-6806831] CYB5Rs reduce MetHb to HbA - Bos taurus [Reaction:R-CFA-6806831] CYB5Rs reduce MetHb to HbA - Canis familiaris [Reaction:R-RNO-6806831] CYB5Rs reduce MetHb to HbA - Rattus norvegicus [Reaction:R-MMU-6806831] CYB5Rs reduce MetHb to HbA - Mus musculus
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [Complex:R-HSA-9033252] HbA [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6806831
summation	[Summation:6806830] NADH-Cytochrome b5 reductases (CYB5Rs), flavoproteins consis...
updateTrackers	[UpdateTracker:9780107] Update Tracker - [Reaction:6806831] CYB5Rs reduce MetHb to HbA - v64:[add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9780107] Update Tracker - [Reaction:6806831] CYB5Rs reduce MetHb to HbA - v64:[add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-1237044] Erythrocytes take up carbon dioxide and release oxygen