Reactome | CYB5Rs reduce MetHb to HbA

CYB5Rs reduce MetHb to HbA

Stable Identifier

R-HSA-6806831

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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NADH-Cytochrome b5 reductases (CYB5Rs), flavoproteins consisting of NADH and flavin adenine dinucleotide (FAD) binding domains, catalyse electron transfer from the two-electron carrier NADH to the one-electron carrier ferricytochrome b5 ((Fe(3+)Cb5), forming ferrocytochrome b5 ((Fe(2+)Cb5) (Zhu et al. 1999, Baker et al. 2005, Zhu et al. 2004). CYB5Rs participate in fatty acid synthesis, cholesterol synthesis and xenobiotic oxidation as members of the electron transport chain on the endoplasmic reticulum membrane. In erythrocytes, CYB5Rs participate in the reduction of methemoglobin (MetHb) to hemoglobin A (HbA).

Literature References

PubMed ID	Title	Journal	Year
10611283	Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells Bunn, HF, Huang, S, Yoon, HW, Zhu, H, Qiu, H	Proc. Natl. Acad. Sci. U.S.A.	1999
15131110	NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum Berchner-Pfannschmidt, U, Ladoux, A, Jackson, TA, Acker, H, Cross, AR, Larade, K, Xie, J, Rodgers, KR, Fandrey, J, Zhu, H, Bunn, HF, Lukat-Rodgers, GS	J. Biol. Chem.	2004
15858218	Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa Curry, BJ, Hetherington, L, Krutskikh, A, Aitken, RJ, Baker, MA	Biol. Reprod.	2005