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Schema
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Reaction
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Entries
EHMT1:EHMT2 dimethylates TP53
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authored
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity
[CatalystActivity:6805758] lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
category
transition
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6805757] Orlic-Milacic, Marija, 2015-10-20
dbId
6805755
displayName
EHMT1:EHMT2 dimethylates TP53
edited
[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf
[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation - Homo sapiens
input
8 ×
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6805760] G9a and Glp methylate lysine 373 in the tumor suppressor p53
maxDepth
1
modified
[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name
EHMT1:EHMT2 dimethylates TP53
orthologousEvent
[Reaction:R-DME-6805755] EHMT1:EHMT2 dimethylates TP53 - Drosophila melanogaster
[Reaction:R-XTR-6805755] EHMT1:EHMT2 dimethylates TP53 - Xenopus tropicalis
[Reaction:R-DRE-6805755] EHMT1:EHMT2 dimethylates TP53 - Danio rerio
[Reaction:R-SSC-6805755] EHMT1:EHMT2 dimethylates TP53 - Sus scrofa
[Reaction:R-BTA-6805755] EHMT1:EHMT2 dimethylates TP53 - Bos taurus
[Reaction:R-CFA-6805755] EHMT1:EHMT2 dimethylates TP53 - Canis familiaris
[Reaction:R-RNO-6805755] EHMT1:EHMT2 dimethylates TP53 - Rattus norvegicus
[Reaction:R-MMU-6805755] EHMT1:EHMT2 dimethylates TP53 - Mus musculus
output
8 ×
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
[Complex:R-HSA-6805762] Me2-K373-TP53 Tetramer [nucleoplasm]
precedingEvent
[Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04
[InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-6805755
summation
[Summation:6805761] The complex of lysine methyltransferases EHMT1 and EHMT2 dim...
Referrals
(hasEvent)
[Pathway:R-HSA-6804760] Regulation of TP53 Activity through Methylation
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