EHMT1:EHMT2 dimethylates TP53

Stable Identifier
R-HSA-6805755
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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EHMT1:EHMT2 dimethylates TP53
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The complex of lysine methyltransferases EHMT1 and EHMT2 dimethylates inactive TP53 at lysine residue K373, resulting in additional inhibition of TP53 activity (Huang et al. 2010).

Literature References
PubMed ID Title Journal Year
20118233 G9a and Glp methylate lysine 373 in the tumor suppressor p53

Huang, J, Dorsey, J, Chuikov, S, Perez-Burgos, L, Zhang, X, Jenuwein, T, Reinberg, D, Berger, SL

J. Biol. Chem. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
Physical Entity
EHMT1:EHMT2 [nucleoplasm]
Activity
lysine N-methyltransferase activity (0016278)
Orthologous Events
EHMT1:EHMT2 dimethylates TP53 (Bos taurus)
EHMT1:EHMT2 dimethylates TP53 (Danio rerio)
EHMT1:EHMT2 dimethylates TP53 (Drosophila melanogaster)
EHMT1:EHMT2 dimethylates TP53 (Mus musculus)
EHMT1:EHMT2 dimethylates TP53 (Rattus norvegicus)
EHMT1:EHMT2 dimethylates TP53 (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-21)