EHMT1:EHMT2 dimethylates TP53

Stable Identifier
R-HSA-6805755
Type
Reaction
Species
Homo sapiens
Compartment
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The complex of lysine methyltransferases EHMT1 and EHMT2 dimethylates inactive TP53 at lysine residue K373, resulting in additional inhibition of TP53 activity (Huang et al. 2010).

Literature References
PubMed ID Title Journal Year
20118233 G9a and Glp methylate lysine 373 in the tumor suppressor p53

Jenuwein, T, Huang, J, Perez-Burgos, L, Dorsey, J, Reinberg, D, Berger, SL, Chuikov, S, Zhang, X

J. Biol. Chem. 2010
Participants
Participates
Catalyst Activity

lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]

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