Reactome | EHMT1:EHMT2 dimethylates TP53

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EHMT1:EHMT2 dimethylates TP53 Show undefined attributes

catalystActivity	[CatalystActivity:10891825] lysine N-methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10891827
displayName	EHMT1:EHMT2 dimethylates TP53
eventOf	[Pathway:R-DME-6804760] Regulation of TP53 Activity through Methylation - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6805755] EHMT1:EHMT2 dimethylates TP53 - Homo sapiens
input	8 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-DME-3209194] TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	EHMT1:EHMT2 dimethylates TP53
output	8 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-DME-6805762] Me2-K373-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-DME-6804762] TP53 forms homotetramers - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-6805755
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-6804760] Regulation of TP53 Activity through Methylation
(inferredTo)	[Reaction:R-HSA-6805755] EHMT1:EHMT2 dimethylates TP53

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