Reactome | AMPK phosphorylates TP53

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AMPK phosphorylates TP53 Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6805465] AMP-activated protein kinase activity of Activated AMPK heterotrimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6805464] Orlic-Milacic, Marija, 2015-10-19
dbId	6805470
displayName	AMPK phosphorylates TP53
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
followingEvent	[Reaction:R-HSA-6805285] PLK3 phosphorylates TP53 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6805462] AMP-activated protein kinase induces a p53-dependent metabolic checkpoint [LiteratureReference:8856545] AMPK couples p73 with p53 in cell fate decision
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	AMPK phosphorylates TP53
orthologousEvent	[Reaction:R-DME-6805470] AMPK phosphorylates TP53 - Drosophila melanogaster [Reaction:R-DRE-6805470] AMPK phosphorylates TP53 - Danio rerio [Reaction:R-SSC-6805470] AMPK phosphorylates TP53 - Sus scrofa [Reaction:R-BTA-6805470] AMPK phosphorylates TP53 - Bos taurus [Reaction:R-CFA-6805470] AMPK phosphorylates TP53 - Canis familiaris [Reaction:R-RNO-6805470] AMPK phosphorylates TP53 - Rattus norvegicus [Reaction:R-MMU-6805470] AMPK phosphorylates TP53 - Mus musculus
output	4 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-349474] p-S15-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6804762] TP53 forms homotetramers - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6805470
summation	[Summation:6805469] AMPK, activated in response to glucose deprivation, phosphor...

Referrals

(hasEvent)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation
(precedingEvent)	[Reaction:R-HSA-6805285] PLK3 phosphorylates TP53

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