Reactome | TP53 stimulates PLAGL1 expression

TP53 stimulates PLAGL1 expression

Stable Identifier

R-HSA-6803946

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
        
        TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
        
        TP53 stimulates PLAGL1 expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the promoter of the PLAGL1 (ZAC1) gene stimulates PLAGL1 transcription (Rozenfeld-Granot et al. 2002). PLAGL1 is a zinc finger protein implicated in transcriptional regulation. PLAGL1 expression correlates with both cell cycle arrest and apoptosis (Spengler et al. 1997) and is frequently lost in cancer (Varrault et al. 1998). The mechanism of PLAGL1 action requires further elucidation.

Literature References

PubMed ID	Title	Journal	Year
9184226	Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain Spengler, D, Villalba, M, Hoffmann, A, Pantaloni, C, Houssami, S, Bockaert, J, Journot, L	EMBO J.	1997
11896574	A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1 Rozenfeld-Granot, G, Krishnamurthy, J, Kannan, K, Toren, A, Amariglio, N, Givol, D, Rechavi, G	Oncogene	2002
9671765	hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer Varrault, A, Ciani, E, Apiou, F, Bilanges, B, Hoffmann, A, Pantaloni, C, Bockaert, J, Spengler, D, Journot, L	Proc. Natl. Acad. Sci. U.S.A.	1998

Participants

Input

PLAGL1 Gene [nucleoplasm] (Homo sapiens)

Output

PLAGL1 [nucleoplasm] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)

This event is regulated

Positively by

Regulator

p-S15,S20-TP53 Tetramer:PLAGL1 Gene [nucleoplasm] (Homo sapiens)

Active Unit

p-S15,S20-TP53 Tetramer [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-10-07)

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