FGFR2b-specific alternative splicing produces FGFR2b transcript

Stable Identifier
R-HSA-6803836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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FGFR2b-specific alternative splicing produces FGFR2b transcript
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In epithelial cells, FGFR2 IIIb-specific alternative splicing is favoured by the binding of ESRP1 and 2, RBFOX2, TIA1 and TIAL1 to the nascent transcript. These proteins, in conjunction with other splicing factors, activate exon IIIb-specific splicing and repress exon IIIc-specific splicing (Warzecha et al, 2009; Baraniak et al, 2006; Mauger et al, 2008; Hovhannisyan and Carstens, 2007; Del Gatto et al, 2000).
Literature References
PubMed ID Title Journal Year
18573884 hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc

Mauger, DM, Lin, C, Garcia-Blanco, MA

Mol. Cell. Biol. 2008
16449636 Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice

Baraniak, AP, Chen, JR, Garcia-Blanco, MA

Mol. Cell. Biol. 2006
17959601 Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons

Hovhannisyan, RH, Carstens, RP

J. Biol. Chem. 2007
10938105 The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site

Del Gatto-Konczak, F, Bourgeois, CF, Le Guiner, C, Kister, L, Gesnel, MC, Stévenin, J, Breathnach, R

Mol. Cell. Biol. 2000
19285943 ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing

Warzecha, CC, Sato, TK, Nabet, B, Hogenesch, JB, Carstens, RP

Mol. Cell 2009
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
Active Unit
HNRNPA1 [nucleoplasm]
PTBP1 [nucleoplasm]
Positively by
Regulator
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
Active Unit
hnRNPH1:hnPNPF:RBFOX2 [nucleoplasm]
TIA1/TIAL1 [nucleoplasm]
ESRP1 [nucleoplasm]
ESRP2 [nucleoplasm]
HNRNPM [nucleoplasm]
Authored
Rothfels, K  (2015-10-07)
Reviewed
Grose, RP  (2016-01-06)
Created
Rothfels, K  (2015-10-07)
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