Reactome | FGFR2b-specific alternative splicing produces FGFR2b transcript

FGFR2b-specific alternative splicing produces FGFR2b transcript

Stable Identifier

R-HSA-6803836

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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FGFR2b-specific alternative splicing produces FGFR2b transcript

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In epithelial cells, FGFR2 IIIb-specific alternative splicing is favoured by the binding of ESRP1 and 2, RBFOX2, TIA1 and TIAL1 to the nascent transcript. These proteins, in conjunction with other splicing factors, activate exon IIIb-specific splicing and repress exon IIIc-specific splicing (Warzecha et al, 2009; Baraniak et al, 2006; Mauger et al, 2008; Hovhannisyan and Carstens, 2007; Del Gatto et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
16449636	Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice Baraniak, AP, Chen, JR, Garcia-Blanco, MA	Mol. Cell. Biol.	2006
18573884	hnRNP H and hnRNP F complex with Fox2 to silence fibroblast growth factor receptor 2 exon IIIc Mauger, DM, Lin, C, Garcia-Blanco, MA	Mol. Cell. Biol.	2008
17959601	Heterogeneous ribonucleoprotein m is a splicing regulatory protein that can enhance or silence splicing of alternatively spliced exons Hovhannisyan, RH, Carstens, RP	J. Biol. Chem.	2007
10938105	The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site Del Gatto-Konczak, F, Bourgeois, CF, Le Guiner, C, Kister, L, Gesnel, MC, Stévenin, J, Breathnach, R	Mol. Cell. Biol.	2000
19285943	ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing Warzecha, CC, Sato, TK, Nabet, B, Hogenesch, JB, Carstens, RP	Mol. Cell	2009