Repression of FGFR2 exon IIIb splicing in mesenchymal cells ...

created [InstanceEdit:6803506] Rothfels, Karen, 2015-10-06
dbId 6803507
displayName Repression of FGFR2 exon IIIb splicing in mesenchymal cells ...
schemaClass Summation
text Repression of FGFR2 exon IIIb splicing in mesenchymal cells depends on intronic splicing silencer (ISS) sequences upstream of exon IIIb as well as an exonic splicing element (ESE) within exon IIIb. These elements are bound by PTB1 and hnRNPA1, respectively, as part of a larger splicing complex, promoting the formation and expression of mature FGFR2c mRNA in mesenchymal cells (Carstens et al, 2000; Gil et al, 1991; Del Gatto et al, 1997; Del Gatto et al, 1999). For more detailed information on splicing and pre-mRNA maturation, please see the mRNA splicing pathway.
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