Reactome | TP53 Regulates Transcription of Death Receptors and Ligands

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TP53 Regulates Transcription of Death Receptors and Ligands Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6803212] Orlic-Milacic, Marija, 2015-10-05
dbId	6803211
displayName	TP53 Regulates Transcription of Death Receptors and Ligands
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5633414] TP53 binds TNFRSF10A,TNFRSF10B,TNFRSF10C,TNFRSF10D genes - Homo sapiens [BlackBoxEvent:R-HSA-5633441] TP53 stimulates transcription of TNFRSF10A, TNFRSF10B,TNFRSF10C and TNFRSF10D genes - Homo sapiens [Reaction:R-HSA-6799815] TP53 family members bind the FAS gene - Homo sapiens [BlackBoxEvent:R-HSA-6800001] TP53 family members stimulate FAS gene expression - Homo sapiens [Reaction:R-HSA-6800042] TP53 binds the IGFBP3 gene - Homo sapiens [BlackBoxEvent:R-HSA-6800044] TP53 stimulates IGFBP3 expression - Homo sapiens [Reaction:R-HSA-6800035] IGFBP3 binds TMEM219 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5633440] Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site [LiteratureReference:5633426] Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site [LiteratureReference:5633429] Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity [LiteratureReference:5633411] p53 upregulates death receptor 4 expression through an intronic p53 binding site [LiteratureReference:5633431] KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene [LiteratureReference:5633427] Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene [LiteratureReference:6799811] Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family [LiteratureReference:6799802] ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo [LiteratureReference:6800029] Induction of the growth inhibitor IGF-binding protein 3 by p53 [LiteratureReference:6800045] Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer
maxDepth	2
modified	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
name	TP53 Regulates Transcription of Death Receptors and Ligands
orthologousEvent	[Pathway:R-DRE-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Danio rerio [Pathway:R-SSC-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Sus scrofa [Pathway:R-BTA-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Bos taurus [Pathway:R-RNO-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Rattus norvegicus [Pathway:R-MMU-6803211] TP53 Regulates Transcription of Death Receptors and Ligands - Mus musculus
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6803211
summation	[Summation:6803208] Pro-apoptotic transcriptional targets of TP53 are TRAIL deat...

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[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes

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