Reactome | TP53 Regulates Transcription of Death Receptors and Ligands

TP53 Regulates Transcription of Death Receptors and Ligands

Stable Identifier

R-HSA-6803211

Type

Pathway

Species

Homo sapiens

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TP53 Regulates Transcription of Death Receptors and Ligands

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Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20353938	Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer Ingermann, AR, Yang, YF, Han, J, Mikami, A, Garza, AE, Mohanraj, L, Fan, L, Idowu, M, Ware, JL, Kim, HS, Lee, DY, Oh, Y	J. Biol. Chem.	2010
23365256	ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A	J. Neurosci.	2013
7566179	Induction of the growth inhibitor IGF-binding protein 3 by p53 Buckbinder, L, Talbott, R, Velasco-Miguel, S, Takenaka, I, Faha, B, Seizinger, BR, Kley, N	Nature	1995
14623878	Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site Ruiz de Almodóvar, C, Ruiz-Ruiz, C, Rodríguez, A, Ortiz-Ferrón, G, Redondo, JM, López-Rivas, A	J. Biol. Chem.	2004
11382926	Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene Guan, B, Yue, P, Clayman, GL, Sun, SY	J. Cell. Physiol.	2001
15289308	p53 upregulates death receptor 4 expression through an intronic p53 binding site Liu, X, Yue, P, Khuri, FR, Sun, SY	Cancer Res.	2004
10777207	Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site Takimoto, R, el-Deiry, WS	Oncogene	2000
19615968	Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family Schilling, T, Schleithoff, ES, Kairat, A, Melino, G, Stremmel, W, Oren, M, Krammer, PH, Müller, M	Biochem. Biophys. Res. Commun.	2009
9326928	KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene Wu, GS, Burns, TF, McDonald, ER, Jiang, W, Meng, R, Krantz, ID, Kao, G, Gan, DD, Zhou, JY, Muschel, R, Hamilton, SR, Spinner, NB, Markowitz, S, Wu, G, el-Deiry, WS	Nat. Genet.	1997
16230375	Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity Liu, X, Yue, P, Khuri, FR, Sun, SY	Cancer Res.	2005