Reactome | Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants

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Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants Show undefined attributes

authored	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
catalystActivity	[CatalystActivity:6802854] protein serine/threonine/tyrosine kinase activity of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802920] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020745] Mondo:0004992
dbId	6802921
disease	[Disease:1500689] cancer
displayName	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
edited	[InstanceEdit:5693873] Rothfels, Karen, 2015-05-18
entityFunctionalStatus	[EntityFunctionalStatus:6802879] gain_of_function of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
eventOf	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants - Homo sapiens
followingEvent	[Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-6802647] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5672469] Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [LiteratureReference:6790314] Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling [LiteratureReference:6790322] Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling [LiteratureReference:6799065] Regulation of RAF protein kinases in ERK signalling
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
normalReaction	[Reaction:R-HSA-5672973] MAP2Ks phosphorylate MAPKs
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-6802648] RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane]
precedingEvent	[Reaction:R-HSA-6802919] RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8933498] Stephens, Robert M, 2016-08-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6802921
summation	[Summation:6802220] MAPKs are phosphorylated downstream of moderately activated ...
updateTrackers	[UpdateTracker:9779822] Update Tracker - [Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants - v64:[add_removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9779822] Update Tracker - [Reaction:6802921] Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants - v64:[add_removeCatalystActivity]
(hasEvent)	[Pathway:R-HSA-6802946] Signaling by moderate kinase activity BRAF mutants
(precedingEvent)	[Reaction:R-HSA-6803230] Dissociation of moderate activity BRAF complexes

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