Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants

Stable Identifier
R-HSA-6802921
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants
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MAPKs are phosphorylated downstream of moderately activated BRAF mutants in a MAP2K-dependent manner (Wan et al, 2004; Roring et al, 2012; Freeman et al, 2013; reviewed in Lavoie and Therrien, 2015).
Literature References
PubMed ID Title Journal Year
25907612 Regulation of RAF protein kinases in ERK signalling

Lavoie, H, Therrien, M

Nat. Rev. Mol. Cell Biol. 2015
22510884 Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling

Röring, M, Herr, R, Fiala, GJ, Heilmann, K, Braun, S, Eisenhardt, AE, Halbach, S, Capper, D, von Deimling, A, Schamel, WW, Saunders, DN, Brummer, T

EMBO J. 2012
23352452 Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling

Freeman, AK, Ritt, DA, Morrison, DK

Mol. Cell 2013
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine/tyrosine kinase activity of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Physical Entity
RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine/tyrosine kinase activity (GO:0004712)
Normal reaction
MAP2Ks phosphorylate MAPKs (Homo sapiens)
Functional status

Gain of function of RAS:GTP:moderate kinase activity p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2015-05-18)
Reviewed
Stephens, RM  (2016-08-05)
Created
Rothfels, K  (2015-10-02)
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