Reactome | TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802702] p-TRIM24-BRAF fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-6802702] p-TRIM24-BRAF fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:6802556] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105
dbId	6802555
disease	[Disease:1500689] cancer [Disease:1614289] melanoma
displayName	TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol]
endCoordinate	510
hasModifiedResidue	[FragmentInsertionModification:6802479] Insertion of residues 381 to 766 at 511 from UniProt:P15056 BRAF [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729 [ModifiedResidue:5672675] O-phospho-L-threonine at 599 [ModifiedResidue:5672677] O-phospho-L-serine at 602
inDisease	true
literatureReference	[LiteratureReference:6800632] BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
maxDepth	1
modified	[InstanceEdit:9753817] Rothfels, Karen, 2021-09-13
name	TRIM24(1-510)-p-BRAF(381-766) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:O15164] UniProt:O15164 TRIM24
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802555
startCoordinate	1
updateTrackers	[UpdateTracker:9902952] Update Tracker - [EntityWithAccessionedSequence:6802555] TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] - v79:[modifyName]

(updatedInstance)	[UpdateTracker:9902952] Update Tracker - [EntityWithAccessionedSequence:6802555] TRIM24(1-510)-p-BRAF(381-766) fusion [cytosol] - v79:[modifyName]
(hasComponent)	[Complex:R-HSA-6802702] p-TRIM24-BRAF fusion dimer [cytosol]

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