Reactome | AGGF(1-290)-p-RAF1(279-648) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802675] p-AGGF1-RAF1 fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-6802675] p-AGGF1-RAF1 fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:6802508] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12021112] Mondo:0005082
dbId	6802507
disease	[Disease:1500689] cancer [Disease:1655494] prostate adenocarcinoma [Disease:6802256] thyroid carcinoma
displayName	AGGF(1-290)-p-RAF1(279-648) fusion [cytosol]
endCoordinate	290
hasModifiedResidue	[FragmentInsertionModification:6802257] Insertion of residues 279 to 648 at 291 from UniProt:P04049 RAF1 [ModifiedResidue:109785] O-phospho-L-serine at 621 [ModifiedResidue:444234] O-phospho-L-serine at 338 [ModifiedResidue:109791] O4'-phospho-L-tyrosine at 341 [ModifiedResidue:5672662] O-phospho-L-threonine at 491 [ModifiedResidue:5672663] O-phospho-L-serine at 494
inDisease	true
literatureReference	[LiteratureReference:6800639] The landscape of kinase fusions in cancer
maxDepth	1
modified	[InstanceEdit:9753817] Rothfels, Karen, 2021-09-13
name	AGGF(1-290)-p-RAF1(279-648) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:Q8N302] UniProt:Q8N302 AGGF1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802507
startCoordinate	1
updateTrackers	[UpdateTracker:9902918] Update Tracker - [EntityWithAccessionedSequence:6802507] AGGF(1-290)-p-RAF1(279-648) fusion [cytosol] - v79:[modifyName]

(updatedInstance)	[UpdateTracker:9902918] Update Tracker - [EntityWithAccessionedSequence:6802507] AGGF(1-290)-p-RAF1(279-648) fusion [cytosol] - v79:[modifyName]
(hasComponent)	[Complex:R-HSA-6802675] p-AGGF1-RAF1 fusion dimer [cytosol]

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