Reactome | KRAS V14I [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:6802481] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:9651291] ClinGen:CA156358 [DatabaseIdentifier:9651292] COSMIC:COSV55501342
dbId	6802480
disease	[Disease:6802289] Noonan syndrome [Disease:4791250] colorectal cancer [Disease:6802336] hematologic cancer
displayName	KRAS V14I [plasma membrane]
endCoordinate	186
hasModifiedResidue	[ReplacedResidue:6802482] L-valine 14 replaced with L-isoleucine
inDisease	true
literatureReference	[LiteratureReference:9651267] Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders
memberOf	[CandidateSet:R-HSA-9649710] RAS GEF mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-9651281] RAS GAP mutants [plasma membrane] - Homo sapiens [CandidateSet:R-HSA-6802608] RAS GTPase mutants [plasma membrane] - Homo sapiens
modified	[InstanceEdit:9651293] Rothfels, Karen, 2019-06-25
name	KRAS V14I
referenceEntity	[ReferenceGeneProduct:62720] UniProt:P01116 KRAS
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802480
startCoordinate	1

(hasMember)