Reactome | PAPSS1(1-223)-BRAF(381-766) fusion [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-6802603] PAPSS1-BRAF fusion dimer [cytosol] - Homo sapiens [Complex:R-HSA-6802603] PAPSS1-BRAF fusion dimer [cytosol] - Homo sapiens
created	[InstanceEdit:6802433] Rothfels, Karen, 2015-10-02
crossReference	[DatabaseIdentifier:12020751] Mondo:0005105
dbId	6802432
disease	[Disease:1614289] melanoma [Disease:1500689] cancer
displayName	PAPSS1(1-223)-BRAF(381-766) fusion [cytosol]
endCoordinate	223
hasModifiedResidue	[FragmentInsertionModification:6802431] Insertion of residues 381 to 766 at 224 from UniProt:P15056 BRAF [ModifiedResidue:5672668] O-phospho-L-serine at 446 [ModifiedResidue:5672670] O-phospho-L-serine at 729
inDisease	true
literatureReference	[LiteratureReference:6800632] BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition
maxDepth	1
modified	[InstanceEdit:9753816] Rothfels, Karen, 2021-09-13
name	PAPSS1(1-223)-BRAF(381-766) fusion
referenceEntity	[ReferenceGeneProduct:uniprot:O43252] UniProt:O43252 PAPSS1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-6802432
startCoordinate	1
updateTrackers	[UpdateTracker:9902940] Update Tracker - [EntityWithAccessionedSequence:6802432] PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] - v79:[modifyName]

(updatedInstance)	[UpdateTracker:9902940] Update Tracker - [EntityWithAccessionedSequence:6802432] PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] - v79:[modifyName]
(hasComponent)	[Complex:R-HSA-6802603] PAPSS1-BRAF fusion dimer [cytosol]

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