Reactome | TP53 stimulates NLRC4 expression

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TP53 stimulates NLRC4 expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6801413] Orlic-Milacic, Marija, 2015-10-01
dbId	6801415
displayName	TP53 stimulates NLRC4 expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-874084] IPAF is activated - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6801358] NLRC4 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6801360] Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis [LiteratureReference:873970] Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1 [LiteratureReference:844443] The inflammasomes [LiteratureReference:451670] Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death [LiteratureReference:6798096] Direct transcriptional activation of human caspase-1 by tumor suppressor p53
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates NLRC4 expression
output	[EntityWithAccessionedSequence:R-HSA-561198] NLRC4 [cytosol]
precedingEvent	[Reaction:R-HSA-6801355] TP53 binds the NLRC4 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-6801412] Positive gene expression regulation by 'p-S15,S20-TP53:NLRC4 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642188] Positive gene expression regulation by 'p-S15,S20-TP53:NLRC4 Gene [nucleoplasm]' Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6801415
summation	[Summation:6801414] The binding of TP53 (p53) to the p53 response element in the...

Referrals

(hasEvent)	[Pathway:R-HSA-6803207] TP53 Regulates Transcription of Caspase Activators and Caspases
(precedingEvent)	[BlackBoxEvent:R-HSA-874084] IPAF is activated

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