TP53 stimulates NLRC4 expression

Stable Identifier
Reaction [omitted]
Homo sapiens
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The binding of TP53 (p53) to the p53 response element in the promoter of the NLRC4 (Ipaf) gene promotes NLRC4 transcription. NLRC4 is an activator of caspase-1 (CASP1) (Poyet et al. 2001), which is also a TP53 target. NLRC4 and CASP1 play an important role in innate immunity via inflammasome-mediated destruction of pathogenic bacteria and fungi (Schroder and Tschopp 2010). NLRC4 contributes to cell death (Sadasivam et al. 2005), possibly through interleukin-1-mediated pyroptosis (Brough and Rothwell 2007).

Literature References
PubMed ID Title Journal Year
11390368 Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

Srinivasula, SM, Tnani, M, Razmara, M, Poyet, JL, Alnemri, ES, Fernandes-Alnemri, T

J Biol Chem 2001
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Furukawa, Y, Swarup, G, Gupta, S, Radha, V

J. Biol. Chem. 2001
20303873 The inflammasomes

Schroder, K, Tschopp, J

Cell 2010
15580302 Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Gupta, S, Radha, V, Kundu, TK, Batta, K, Swarup, G, Sadasivam, S

Oncogene 2005
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Rothwell, NJ, Brough, D

J Cell Sci 2007
This event is regulated