TP53 stimulates NLRC4 expression

Stable Identifier
R-HSA-6801415
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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TP53 stimulates NLRC4 expression
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The binding of TP53 (p53) to the p53 response element in the promoter of the NLRC4 (Ipaf) gene promotes NLRC4 transcription. NLRC4 is an activator of caspase-1 (CASP1) (Poyet et al. 2001), which is also a TP53 target. NLRC4 and CASP1 play an important role in innate immunity via inflammasome-mediated destruction of pathogenic bacteria and fungi (Schroder and Tschopp 2010). NLRC4 contributes to cell death (Sadasivam et al. 2005), possibly through interleukin-1-mediated pyroptosis (Brough and Rothwell 2007).
Literature References
PubMed ID Title Journal Year
11390368 Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1

Poyet, JL, Srinivasula, SM, Tnani, M, Razmara, M, Fernandes-Alnemri, T, Alnemri, ES

J Biol Chem 2001
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Gupta, S, Radha, V, Furukawa, Y, Swarup, G

J. Biol. Chem. 2001
20303873 The inflammasomes

Schroder, K, Tschopp, J

Cell 2010
15580302 Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S, Gupta, S, Radha, V, Batta, K, Kundu, TK, Swarup, G

Oncogene 2005
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Brough, D, Rothwell, NJ

J Cell Sci 2007
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53:NLRC4 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2015-10-01)
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