Reactome | MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

Schema > Reaction > Entries

MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man Show undefined attributes

authored	[InstanceEdit:6799498] Jassal, Bijay, 2015-09-25
catalystActivity	[CatalystActivity:6799586] mannan endo-1,6-alpha-mannosidase activity of MAN2B2:Zn2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:6799574] Jassal, Bijay, 2015-09-25
dbId	6799581
displayName	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
edited	[InstanceEdit:6799498] Jassal, Bijay, 2015-09-25
eventOf	[Pathway:R-HSA-8853383] Lysosomal oligosaccharide catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-8853710] MANBA hydrolyses GlcNAc:Man - Homo sapiens
input	[SimpleEntity:R-ALL-6799577] alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6799587] Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties [LiteratureReference:6799580] Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
orthologousEvent	[Reaction:R-DDI-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Dictyostelium discoideum [Reaction:R-CEL-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Caenorhabditis elegans [Reaction:R-DME-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Drosophila melanogaster [Reaction:R-GGA-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Gallus gallus [Reaction:R-XTR-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Xenopus tropicalis [Reaction:R-DRE-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Danio rerio [Reaction:R-SSC-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Sus scrofa [Reaction:R-BTA-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Bos taurus [Reaction:R-MMU-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Mus musculus
output	[SimpleEntity:R-ALL-8853719] GlcNAc:Man [lysosomal lumen] 2 × [SimpleEntity:R-ALL-6799594] Man [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-8853686] MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8851787] D'Eustachio, Peter, 2016-01-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799581
summation	[Summation:6799583] Endoplasmic reticulum-associated degradation of misfolded gl...

Referrals

(hasEvent)	[Pathway:R-HSA-8853383] Lysosomal oligosaccharide catabolism
(precedingEvent)	[Reaction:R-HSA-8853710] MANBA hydrolyses GlcNAc:Man