Reactome | MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

Schema > Reaction > Entries

MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man Show undefined attributes

catalystActivity	[CatalystActivity:10801911] mannan endo-1,6-alpha-mannosidase activity of MAN2B2:Zn2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10801913
displayName	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
eventOf	[Pathway:R-GGA-8853383] Lysosomal oligosaccharide catabolism - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-8853710] MANBA hydrolyses GlcNAc:Man - Gallus gallus
inferredFrom	[Reaction:R-HSA-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Homo sapiens
input	[SimpleEntity:R-ALL-6799577] alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
output	[SimpleEntity:R-ALL-8853719] GlcNAc:Man [lysosomal lumen] 2 × [SimpleEntity:R-ALL-6799594] Man [lysosomal lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-6799581
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-8853383] Lysosomal oligosaccharide catabolism
(precedingEvent)	[Reaction:R-GGA-8853710] MANBA hydrolyses GlcNAc:Man
(inferredTo)	[Reaction:R-HSA-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

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